The S521 is an S series solid body electric guitar introduced by Ibanez in 2014. It is produced in Indonesia.
The S521 features a mahogany body bolted to a maple Wizard III neck with a 24-fret rosewood fingerboard with offset dot position markers. Components include dual Ibanez Quantum humbucking pickups and a fixed bridge.
For 2018 the rosewood fretboard was replaced by jatoba.
The S521L is a left-handed version. The S520 is a similar model with a double locking tremolo bridge. The S621QM is a similar model with a quilted maple top.